4-Hydroxymethylpyridine → 2,3-Dichloro-N-[5-chloro-3-(4-pyridinylmethoxy)-2-pyrazinyl]benzenesulphonamide

HRID 1444001노트

반응식

HRID 1444001 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][OH:8])=[CH:3][CH:2]=1.[Cl:9][C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][C:11]=1[S:17]([NH:20][C:21]1[C:26](Cl)=[N:25][C:24]([Cl:28])=[CH:23][N:22]=1)(=[O:19])=[O:18]>>[Cl:9][C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][C:11]=1[S:17]([NH:20][C:21]1[C:26]([O:8][CH2:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)=[N:25][C:24]([Cl:28])=[CH:23][N:22]=1)(=[O:19])=[O:18]

참가 물질

3

반응물 2

HCID 114724-HydroxymethylpyridineHCID 101263402,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide

생성물 1

HCID 103104262,3-Dichloro-N-[5-chloro-3-(4-pyridinylmethoxy)-2-pyrazinyl]benzenesulphonamide

실험 절차

Prepared by the method of Example 31b using pyridine-4-methanol (0.4 g) and 2,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide (Example 74) (0.4 g). Yield 0.47 g.

후처리

  1. customPrepared by the method of Example 31b

출처 및 근거

ORD 기록
ord-f89ff64b291a4a97a2f3316d939329ac
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662825B2

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