Acetonitrile → HCID 67139353, compound

Participants

Reaction Steps

A mixture of 2,3-dichloro-N-[5-chloro-3-(3-pyridinylmethoxy)-2-pyrazinyl]-N-[2-trimethylsilanylethoxymethyl]benzenesulphonamide (Example 101a) (0.68 g), caesium carbonate (1.9 g) and 2-aminoethanethiol hydrochloride (0.2 g) in acetonitrile (5 mL) was stirred at room temperature for 5 h. Ethyl acetate was added and the mixture washed with water and brine. The organic layer was dried (MgSO4) and evaporated. The residue was dissolved in trifluoracetic acid. After 1 h, toluene was added and the mixture evaporated to dryness. HCl (1M in dioxane) was added and the solid collected by filtration (0.2 g).

Provenance & Evidence