3-Fluorobenzenesulfonyl Chloride → N-(5-Chloro-3-methoxy-2-pyrazinyl)-3-fluorobenzenesulphonamide

HRID 1444032Notes

Reaction equation

HRID 1444032 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([O:9][CH3:10])[C:5]([NH2:8])=[N:6][CH:7]=1.[F:11][C:12]1[CH:13]=[C:14]([S:18](Cl)(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1>>[Cl:1][C:2]1[N:3]=[C:4]([O:9][CH3:10])[C:5]([NH:8][S:18]([C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([F:11])[CH:13]=2)(=[O:20])=[O:19])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 107970362-Amino-5-chloro-3-methoxypyrazine

Product 1

HCID 59168098N-(5-Chloro-3-methoxy-2-pyrazinyl)-3-fluorobenzenesulphonamide

Procedure

By the method outlined in Example 1 (reaction performed at room temperature) using 5-chloro-3-methoxy-2-pyrazinamine (0.798 g) and 3-fluorobenzenesulphonyl chloride (1.17 g). Yield 0.64 g.

Workup

  1. customBy the method outlined in Example 1 (reaction performed at room temperature)

Sources & evidence

ORD record
ord-0167e3a59e9745539ca3adec05ddf5bd
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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