Ammonia → 5-{[(2,3-Dichlorophenyl)sulphonyl]amino}-6-(3-pyridinylmethoxy)-2-pyrazinecarboxamide

HRID 1444039Notes

Reaction equation

HRID 1444039 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[N:14]=[CH:15][C:16]([C:27]([O:29]C)=O)=[N:17][C:18]=1[O:19][CH2:20][C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)(=[O:11])=[O:10].[NH3:31]>CO>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[N:14]=[CH:15][C:16]([C:27]([NH2:31])=[O:29])=[N:17][C:18]=1[O:19][CH2:20][C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)(=[O:10])=[O:11]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 59168105HCID 59168105, compound

Product 1

HCID 591681905-{[(2,3-Dichlorophenyl)sulphonyl]amino}-6-(3-pyridinylmethoxy)-2-pyrazinecarboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(2,3-Dichlorobenzenesulphonylamino)-6-(3-pyridinylmethoxy)pyrazine-2-carboxylic acid, methyl ester (Example 134) (0.05 g) was heated at 60° C. in 7M ammonia in methanol for 4 days. The solution was evaporated to dryness and the product crystallised from methyl acetate. Yield 0.027 g.

Workup

  1. customThe solution was evaporated to dryness
  2. customthe product crystallised from methyl acetate

Sources & evidence

ORD record
ord-a9a642264a4646aeb95345c5b7346240
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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