2-Mercaptoethanol → HCID 10126886, compound

HRID 1444054Notes

Reaction equation

HRID 1444054 reaction equation
Br[C:2]1[N:3]=[C:4]([O:28][CH3:29])[C:5]([N:8](COCC[Si](C)(C)C)[S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])(=[O:11])=[O:10])=[N:6][CH:7]=1.[SH:30][CH2:31][CH2:32][OH:33]>>[Cl:19][C:13]1[C:14]([Cl:18])=[CH:15][CH:16]=[CH:17][C:12]=1[S:9]([NH:8][C:5]1[C:4]([O:28][CH3:29])=[N:3][C:2]([S:30][CH2:31][CH2:32][OH:33])=[CH:7][N:6]=1)(=[O:10])=[O:11]

Participants

3

Reactant 2

HCID 15672-MercaptoethanolHCID 59168156N-(5-Bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide

Product 1

HCID 10126886HCID 10126886, compound

Procedure

Prepared as for Example 101b using N-(5-bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide (Example 55a) (0.2 g) and 2-mercaptoethanol (0.2 g). After removal of the SEM (2-[trimethylsilyl]ethoxymethyl) group the title compound was purified by silica gel chromatography eluting with methanol/dichloromethane mixtures. Yield 0.015 g

Workup

  1. customPrepared as for Example 101b
  2. customAfter removal of the SEM (2-[trimethylsilyl]ethoxymethyl) group the title compound
  3. customwas purified by silica gel chromatography
  4. washeluting with methanol/dichloromethane mixtures

Sources & evidence

ORD record
ord-00942d4e10db47d396766865f8511324
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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