Ethyl isocyanate → HCID 10127990, compound

HRID 1444055Notes

Reaction equation

HRID 1444055 reaction equation
[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2].[NH2:6][CH2:7][CH2:8][S:9][C:10]1[N:11]=[C:12]([O:28][CH3:29])[C:13]([NH:16][S:17]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=2[Cl:27])(=[O:19])=[O:18])=[N:14][CH:15]=1>ClCCl>[Cl:27][C:21]1[C:22]([Cl:26])=[CH:23][CH:24]=[CH:25][C:20]=1[S:17]([NH:16][C:13]1[C:12]([O:28][CH3:29])=[N:11][C:10]([S:9][CH2:8][CH2:7][NH:6][C:4]([NH:3][CH2:1][CH3:2])=[O:5])=[CH:15][N:14]=1)(=[O:18])=[O:19]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 59168135HCID 59168135, compound

Product 1

HCID 10127990HCID 10127990, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethylisocyanate (0.016 g) was added to N-[5-(2-aminoethylsulphanyl)-3-methoxy-2-pyrazinyl]-2,3-dichloro-benzenesulphonamide (Example 173) (0.08 g) in dichloromethane (5 mL). After 1 h, the reaction mixture was evaporated to dryness. Purified by silica gel chromatography eluting with methanol/dichloromethane mixtures. Yield 0.015 g.

Workup

  1. customthe reaction mixture was evaporated to dryness
  2. customPurified by silica gel chromatography
  3. washeluting with methanol/dichloromethane mixtures

Sources & evidence

ORD record
ord-b9c8f36c5a774b1a8f525aba2fb600ad
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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