5-((Dimethylamino)methyl)-2-furanmethanol → HCID 59168139, compound

HRID 1444058Notes

Reaction equation

HRID 1444058 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][OH:11])=[CH:7][CH:6]=1)[CH3:3].[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20]([NH:23][C:24]1[C:29](Cl)=[N:28][C:27]([Cl:31])=[CH:26][N:25]=1)(=[O:22])=[O:21]>>[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20]([NH:23][C:24]1[C:29]([O:11][CH2:10][C:8]2[O:9][C:5]([CH2:4][N:2]([CH3:1])[CH3:3])=[CH:6][CH:7]=2)=[N:28][C:27]([Cl:31])=[CH:26][N:25]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 849065-((Dimethylamino)methyl)-2-furanmethanolHCID 101263402,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide

Product 1

HCID 59168139HCID 59168139, compound

Procedure

Prepared by the method of Example 31 using (5-dimethylaminomethyl-2-furanyl)methanol (0.3 g) and 2,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide (Example 74) (0.4 g). Purified by silica gel chromatography eluting with methanol/dichloromethane mixtures. Yield 0.30 g.

Workup

  1. customPurified by silica gel chromatography
  2. washeluting with methanol/dichloromethane mixtures

Sources & evidence

ORD record
ord-5ce76b37fcec4fb7a7c54d4322b873b8
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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