2-Amino-5-bromo-3-methoxypyrazine → N-(5-Bromo-3-methoxypyrazinyl)-2,3-dichloro-4-fluorobenzenesulphonamide

HRID 1444062Notes

Reaction equation

HRID 1444062 reaction equation
[Br:1][C:2]1[N:3]=[C:4]([O:9][CH3:10])[C:5]([NH2:8])=[N:6][CH:7]=1.[Cl:11][C:12]1[C:17]([Cl:18])=[C:16]([F:19])[CH:15]=[CH:14][C:13]=1[S:20](Cl)(=[O:22])=[O:21]>>[Br:1][C:2]1[N:3]=[C:4]([O:9][CH3:10])[C:5]([NH:8][S:20]([C:13]2[CH:14]=[CH:15][C:16]([F:19])=[C:17]([Cl:18])[C:12]=2[Cl:11])(=[O:22])=[O:21])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 113447242-Amino-5-bromo-3-methoxypyrazineHCID 591682102,3-Dichloro-4-fluorobenzenesulphonyl chloride

Product 1

HCID 59168138N-(5-Bromo-3-methoxypyrazinyl)-2,3-dichloro-4-fluorobenzenesulphonamide

Procedure

Prepared by the method of Example 1 (reaction performed at room temperature) using 5-bromo-3-methoxy-2-pyrazinamine (0.2 g) and 2,3-dichloro-4-fluorobenzenesulphonyl chloride (Example 185a) (0.31 g). Yield 0.042 g.

Workup

  1. customPrepared by the method of Example 1 (reaction performed at room temperature)

Sources & evidence

ORD record
ord-bef5fd6257e9484694f9471f6ff2c643
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

Loading…