(5-(Aminomethyl)furan-2-yl)methanol → HCID 59168191, compound

HRID 1444073Notes

Reaction equation

HRID 1444073 reaction equation
[NH2:1][CH2:2][C:3]1[O:7][C:6]([CH2:8][OH:9])=[CH:5][CH:4]=1.[Cl:10][C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[CH:13][C:12]=1[S:18]([NH:21][C:22]1[C:27](Cl)=[N:26][C:25]([Cl:29])=[CH:24][N:23]=1)(=[O:20])=[O:19]>>[NH2:1][CH2:2][C:3]1[O:7][C:6]([CH2:8][O:9][C:27]2[C:22]([NH:21][S:18]([C:12]3[CH:13]=[CH:14][CH:15]=[C:16]([Cl:17])[C:11]=3[Cl:10])(=[O:20])=[O:19])=[N:23][CH:24]=[C:25]([Cl:29])[N:26]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 448213(5-(Aminomethyl)furan-2-yl)methanolHCID 101263402,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide

Product 1

HCID 59168191HCID 59168191, compound

Procedure

Prepared by the method of Example 31 using (5-aminomethyl-2-furanyl)methanol (0.2 g) and 2,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide (Example 74) (0.3 g). Purified by silica gel chromatography eluting with methanol/dichloromethane mixtures.

Workup

  1. customPurified by silica gel chromatography
  2. washeluting with methanol/dichloromethane mixtures

Sources & evidence

ORD record
ord-0836c02779a442748d068663f2344e75
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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