Sodium hydride → {[5-(2,3-Dichlorophenylsulfonylamino)-6-methoxy-2-pyrazinyl]oxy}acetic acid, methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Sodium hydride	HCID 24758	—
Reactant	Methyl Glycolate	HCID 66774	—
Reactant	2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)-N-({2-[(trimethylsilyl)oxy]ethoxy}methyl)benzenesulphonamide	HCID 86602800	—
Solvent	Dimethylformamide	HCID 6228	—
Product	{[5-(2,3-Dichlorophenylsulfonylamino)-6-methoxy-2-pyrazinyl]oxy}acetic acid, methyl ester	HCID 59168215	—

Reaction Steps

Procedure as for Example 115 using 2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)-N-({2-[(trimethylsilyl)oxy]ethoxy}methyl)benzenesulphonamide (Example 115a) (0.26 g), methyl glycolate (0.075 mL) and sodium hydride (0.035 g of a 60% dispersion in oil) in N,N-dimethylformamide (5 mL). Yield 0.1 g

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07662825B2
Source dataset	uspto-grants-2010_02
ORD ID	ord-262f7ca40dea46ae814a47e113e89bf5
Source note	uspto-grants-2010_02