反应详情

Heat a mixture of 4,6-dichloro-2-(2-methylpyrrolidin-1-yl)pyrimidine (2.25 g, 9.74 mmol), 4-fluorophenylboronic acid (10.23 mmol), Pd(PPh3)4 (562 mg, 0.487 mmol), and a 2M potassium phosphate solution (9.74 mL) in dioxane (35 mL) under nitrogen at 80° C. for 16 h. Evaporate the mixture and add water (50 mL). Extract with EtOAc (3×50 mL), dry (Na2SO4), and evaporate. Purify by SiO2 flash chromatography, eluting with 9:1 hexanes:EtOAc to provide the title compound as an oil.

1. temperatureHeat
2. customEvaporate the mixture
3. additionadd water (50 mL)
4. extractionExtract with EtOAc (3×50 mL)
5. dry with materialdry (Na2SO4)
6. customevaporate
7. customPurify by SiO2 flash chromatography
8. washeluting with 9:1 hexanes