HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(3-Methyl-5-nitropyridin-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Chloro-3-methyl-5-nitropyridine | HCID 89648 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-(3-Methyl-5-nitropyridin-2-yl)piperazine | HCID 56687060 | — |
Reaction Steps
1-(3-Methyl-5-nitro-pyridin-2-yl)-piperazine is prepared by heating a solution of 1 g of 2-chloro-3-methyl-5-nitro-pyridine (Maybridge Chemical Company Ltd.) and piperazine (5 g) in DMA at 110° C. for 16 h. Partition between EtOAc and water and wash the organic layer with water (2×). Dry the organic layer with Na2SO4 and concentrate to give crude product. Purify via flash chromatography eluting with MeOH:DCM:NH4OH (9:90:1) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662830B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-04783798189b4673833303e195f80c28 |
| Source note | uspto-grants-2010_02 |