反应详情

A solution of 2-bromoimidazo[5,1-b]thiazole-7-carboxylic acid (22 mg, 0.09 mmol) in dimethyl sulfoxide (1 ml) was stirred at 180° C. for 2 hr. Thereafter, the reaction solution was allowed to cool to room temperature and was then concentrated by removal of the solvent under the reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate:methanol=60:1) to give 2-bromoimidazo[5,1-b]thiazole (4 mg, 20%) as a white solid.

1. concentrationwas then concentrated by removal of the solvent under the reduced pressure
2. customThe residue was purified by column chromatography on silica gel (ethyl acetate:methanol=60:1)