Sodium Hydroxide → 2-Bromoimidazo[5,1-b]thiazole

Participants

Reaction Steps

A solution of 2-bromoimidazo[5,1-b]thiazole-7-carboxylic acid (28 mg, 0.11 mmol) in ethylene glycol (1 ml) was stirred at 180° C. for 2.5 hr. The reaction solution was allowed to cool to room temperature, a 2.7 M aqueous solution (5 ml) of sodium hydroxide was added to the cooled solution, and the mixture was extracted with ethyl acetate (5 ml×3). The organic layer was washed with saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure to give 2-bromoimidazo[5,1-b]thiazole (11 mg, 48%) as a crude product.

Provenance & Evidence