2-Bromoimidazo(4,3-b)(1,3)thiazole-7-carboxylic acid → 2-Bromoimidazo[5,1-b]thiazole

Participants

Reaction Steps

A solution of 2-bromoimidazo[5,1-b]thiazole-7-carboxylic acid (36 mg, 0.14 mmol) in acetic acid (1 ml) was heated under reflux for 2 days. The reaction solution was allowed to cool to room temperature and was then concentrated by removal of the solvent under the reduced pressure, and the residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1) to give 2-bromoimidazo[5,1-b]thiazole (4 mg, 14%) as a white solid.

Provenance & Evidence