2-Bromo-7-hydroxymethylimidazo[5,1-b]thiazole → 2-Bromoimidazo[5,1-b]thiazole-7-carbaldehyde

Participants

Reaction Steps

Manganese dioxide (content 75%; 5.3 g, 46.11 mmol) was added to a solution of 2-bromo-7-hydroxymethylimidazo[5,1-b]thiazole (1.1 g, 4.61 mmol) in dichloromethane (100 ml), and the mixture was heated under reflux for 30 min. After the completion of the reaction, the reaction mixture was filtered through Celite, followed by washing with dichloromethane. The solvent was then removed by distillation under the reduced pressure to give 2-bromoimidazo[5,1-b]thiazole-7-carbaldehyde (989 mg, 93%) as a white solid.

Provenance & Evidence