Thionyl Chloride → HCID 59168400, compound

Participants

Reaction Steps

Thionyl chloride (0.1 ml, 1.37 mmol) was added dropwise to a solution of 2-bromoimidazo[5,1-b]thiazole-7-carboxylic acid (97 mg, 0.39 mmol) in toluene (10 ml), and the mixture was heated under reflux for 1.5 hr. The excessive amount of thionyl chloride was removed at the atmospheric pressure, and the solvent was then removed by distillation under the reduced pressure to give 2-bromoimidazo[5,1-b]thiazole-7-carboxylic acid chloride (104 mg, quantitative) as a light brown solid.

Provenance & Evidence