5-Bromo-2-furanecarboxylic acid → (3-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl)-acetic Acid Methyl Ester

HRID 1444209Notes

Reaction equation

HRID 1444209 reaction equation
[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([NH2:11])[CH:6]=1.[Br:13][C:14]1[O:18][C:17]([C:19](O)=[O:20])=[CH:16][CH:15]=1>>[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([NH:11][C:19]([C:17]2[O:18][C:14]([Br:13])=[CH:15][CH:16]=2)=[O:20])[CH:6]=1

Participants

3

Reactant 2

HCID 685115-Bromo-2-furanecarboxylic acidHCID 13054266Methyl 3-aminophenylacetate

Product 1

HCID 59654700(3-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl)-acetic Acid Methyl Ester

Procedure

Methyl ester (15) (1 g, 6.06 mmol) was coupled to 5-bromo-furan-2-carboxylic acid (1.16 g, 6.07 mmol) using Method C to give the title compound

Sources & evidence

ORD record
ord-622084b34b0b42a187850adc704f1448
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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