5-Bromothiophene-2-carboxylic acid → HCID 59654739, compound

HRID 1444236Notes

Reaction equation

HRID 1444236 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.[CH2:10]([O:12][C:13](=[O:22])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([NH2:21])[CH:16]=1)[CH3:11]>>[CH2:10]([O:12][C:13](=[O:22])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:7]([C:5]2[S:6][C:2]([Br:1])=[CH:3][CH:4]=2)=[O:9])[CH:16]=1)[CH3:11]

Participants

3

Reactant 2

HCID 3491155-Bromothiophene-2-carboxylic acidHCID 13042040Ethyl 2-(3-aminophenyl)acetate

Product 1

HCID 59654739HCID 59654739, compound

Procedure

5-Bromothiophene-2-carboxylic acid (232 mg, 1.1 mmol) was coupled with ethyl ester (6) (201 mg, 1.1 mmol) following Method C to give the title compound.

Sources & evidence

ORD record
ord-c4c882bf227d4a3a80a0f678fd873d35
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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