3-Bromo-4-fluorobenzoic acid → HCID 59654771, compound

HRID 1444242Notes

Reaction equation

HRID 1444242 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=O.[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][C:10]([F:11])=[C:2]([Br:1])[CH:3]=2)[CH:18]=1)[CH3:13]

Participants

3

Reactant 2

HCID 705093-Bromo-4-fluorobenzoic acidHCID 13042040Ethyl 2-(3-aminophenyl)acetate

Product 1

HCID 59654771HCID 59654771, compound

Procedure

3-Bromo-4-fluorobenzoic acid (123 mg, 0.56 mmol) was coupled with ethyl ester (6) (100 mg, 0.56 mmol) following Method C to give the title compound.

Sources & evidence

ORD record
ord-a472b5f0c9e14c9b81554df14b3c0c5b
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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