4-Bromo-2-methylbenzoic acid → HCID 59654624, compound

HRID 1444244Notes

Reaction equation

HRID 1444244 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[CH:3]=1.[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:6](=[O:8])[C:5]2[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][C:4]=2[CH3:11])[CH:18]=1)[CH3:13]

Participants

3

Reactant 2

HCID 995704-Bromo-2-methylbenzoic acidHCID 13042040Ethyl 2-(3-aminophenyl)acetate

Product 1

HCID 59654624HCID 59654624, compound

Procedure

4-Bromo-2-methylbenzoic acid (120 mg, 0.56 mmol) was coupled with ethyl ester (6) (100 mg, 0.56 mmol) following Method C to give the title compound

Sources & evidence

ORD record
ord-a83e199ece534c5dbb293cdc36fc9f69
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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