Methanol → Methyl 3-(3-aminophenyl)propanoate

HRID 1444266Notes

Reaction equation

HRID 1444266 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([NH2:1])[CH:3]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 27354063-(3-Aminophenyl)propionic acid

Product 1

HCID 10442275Methyl 3-(3-aminophenyl)propanoate

Procedure

3-(3-Amino-phenyl)-propionic acid (495 mg, 3 mmol) was esterified with MeOH using Method A, except that the residue was partitioned between EtOAc (10 ml) and saturated aqueous NaHCO3 (10 ml). The organic layer was dried (MgSO4), filtered and evaporated in vacuo to give the title compound.

Workup

  1. customwas partitioned between EtOAc (10 ml) and saturated aqueous NaHCO3 (10 ml)
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-81a61f89cea84a1d883040cb35528e3f
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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