Azido(trimethyl)stannane → HCID 178522031, compound

HRID 1444288Notes

Reaction equation

HRID 1444288 reaction equation
[C:1]([CH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]([C:13]2[O:14][C:15]([Br:18])=[CH:16][CH:17]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)#[N:2].[Sn]([N:23]=[N+:24]=[N-:25])(C)(C)C>>[NH:23]1[C:1]([CH2:3][C:4]2[CH:5]=[C:6]([NH:10][C:11]([C:13]3[O:14][C:15]([Br:18])=[CH:16][CH:17]=3)=[O:12])[CH:7]=[CH:8][CH:9]=2)=[N:2][N:25]=[N:24]1

Participants

3

Reactant 2

HCID 5104973Azido(trimethyl)stannaneHCID 596548595-Bromo-furan-2-carboxylic acid (3-cyanomethyl-phenyl)-amide

Product 1

HCID 178522031HCID 178522031, compound

Procedure

Nitrile (83) (162 mg, 0.53 mmol) was treated with Me3SnN3 using Method K. The residue was purified by column chromatography, flushing with heptane (200 ml) and eluting with 50% EtOAc in heptane to give the title compound.

Workup

  1. customThe residue was purified by column chromatography
  2. customflushing with heptane (200 ml)
  3. washeluting with 50% EtOAc in heptane

Sources & evidence

ORD record
ord-2328271765a4498bb5ca149e8da0dae3
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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