5-Phenylfuran-2-carboxylic acid → 5-[(5-Phenyl-furan-2-carbonyl)-amino]-benzo[b]thiophene-2-carboxylic acid ethyl ester

HRID 1444301Notes

Reaction equation

HRID 1444301 reaction equation
[C:1]1([C:7]2[O:11][C:10]([C:12]([OH:14])=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15]([O:17][C:18]([C:20]1[S:21][C:22]2[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][C:23]=2[CH:24]=1)=[O:19])[CH3:16]>>[CH2:15]([O:17][C:18]([C:20]1[S:21][C:22]2[CH:28]=[CH:27][C:26]([NH:29][C:12]([C:10]3[O:11][C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)=[CH:8][CH:9]=3)=[O:14])=[CH:25][C:23]=2[CH:24]=1)=[O:19])[CH3:16]

Participants

3

Reactant 2

HCID 7362555-Phenylfuran-2-carboxylic acidHCID 2764450Ethyl 5-amino-1-benzothiophene-2-carboxylate

Product 1

HCID 596547885-[(5-Phenyl-furan-2-carbonyl)-amino]-benzo[b]thiophene-2-carboxylic acid ethyl ester

Procedure

Carboxylic acid (56) (105 mg, 0.56 mmol) was coupled to 5-amino-benzothiophene-2-carboxylic acid ethyl ester (123 mg, 0.56 mmol) using Method C to give the title compound.

Sources & evidence

ORD record
ord-6d8251d258544a0c82be280c912dba49
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

Loading…