HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1444308Generated: October 31, 2026
3-Benzyloxy-phenylboronic acid → 3-(3-{[5-(3-Benzyloxy-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
https://huagongshe.com/reaction/1444308
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Benzyloxy-phenylboronic acid | HCID 2734313 | — |
| Reactant | 3-{3-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68494560 | — |
| Product | 3-(3-{[5-(3-Benzyloxy-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68498158 | — |
Reaction Steps
The furyl bromide (99) (100 mg, 0.28 mmol) was coupled to 3-benzyloxy-phenylboronic acid (69 mg, 0.30 mmol) acid using Method E, except that the reaction was heated at 85° C. The crude product was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07662839B2 |
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| Source dataset | uspto-grants-2010_02 |
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| ORD ID | ord-77c2f4237b1b453bac2b9a2f679eacdf |
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| Source note | uspto-grants-2010_02 |
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