HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1444309Generated: November 1, 2026
2-Fluoro-4-biphenylboronic Acid → 3-(3-{[5-(2-Fluoro-biphenyl-4-yl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
https://huagongshe.com/reaction/1444309
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Fluoro-4-biphenylboronic Acid | HCID 2774698 | — |
| Reactant | 3-{3-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68494560 | — |
| Product | 3-(3-{[5-(2-Fluoro-biphenyl-4-yl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68497012 | — |
Reaction Steps
The furyl bromide (99) (100 mg, 0.28 mmol) was coupled to 2-Fluoro-biphenyl-4-boronic acid (65 mg, 0.30 mmol) acid using Method E, except that the reaction was heated at 85° C. The crude product was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07662839B2 |
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| Source dataset | uspto-grants-2010_02 |
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| ORD ID | ord-10501dfdedbf4a619e38a7d7808b222d |
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| Source note | uspto-grants-2010_02 |
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