HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenylboronic acid → 3-{3-[(4,3'-Difluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | 3-[3-(5-Bromo-2-fluoro-benzoylamino)-phenyl]-acrylic acid ethyl ester | HCID 68497072 | — |
| Product | 3-{3-[(4,3'-Difluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68497407 | — |
Reaction Steps
The phenyl bromide (106) (100 mg, 0.25 mmol) was coupled to 3-fluoro-phenylboronic acid (39 mg, 0.28 mmol) using Method E. The crude product was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662839B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-67872adc03b64bf1a1985e01322a4012 |
| Source note | uspto-grants-2010_02 |