3-Aminocinnamic acid ethyl ester → HCID 68496396, compound

HRID 1444335Notes

Reaction equation

HRID 1444335 reaction equation
[C:1]12([C:11]3[O:15][C:14]([C:16](O)=[O:17])=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH2:19]([O:21][C:22](=[O:32])[CH:23]=[CH:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([NH2:31])[CH:26]=1)[CH3:20]>>[CH2:19]([O:21][C:22](=[O:32])[CH:23]=[CH:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([NH:31][C:16]([C:14]2[O:15][C:11]([C:1]34[CH2:10][CH:5]5[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]5)[CH2:8]3)[CH2:2]4)=[CH:12][CH:13]=2)=[O:17])[CH:26]=1)[CH3:20]

Participants

3

Reactant 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 2973331HCID 2973331, compound

Product 1

HCID 68496396HCID 68496396, compound

Procedure

5-Adamantan-1-yl-furan-2-carboxylic acid (50 mg, 0.20 mmol) was coupled to aniline (60) (43 mg, 0.22 mmol) using Method D to give the title compound.

Sources & evidence

ORD record
ord-49c49c6714f6451598fd4d4ad5ebb617
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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