Ethyl 3-(3-Aminophenyl)propionate → HCID 59654852, compound

HRID 1444346Notes

Reaction equation

HRID 1444346 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[C:13]([C:15]([OH:17])=O)[CH:12]=[CH:11][CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:18]([O:20][C:21](=[O:31])[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH2:30])[CH:25]=1)[CH3:19]>>[CH2:18]([O:20][C:21](=[O:31])[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH:30][C:15]([C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([C:4]3[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:14]=2)=[O:17])[CH:25]=1)[CH3:19]

Participants

3

Reactant 2

HCID 82314Ethyl 3-(3-Aminophenyl)propionateHCID 24730153HCID 24730153, compound

Product 1

HCID 59654852HCID 59654852, compound

Procedure

Carboxylic acid (131) (50 mg, 0.19 mmol) was coupled to aniline (124) (40 mg, 0.21 mmol) using Method D to give the product, which was used without further purification.

Workup

  1. customto give the product, which
  2. customwas used without further purification

Sources & evidence

ORD record
ord-95feaba8ac64490bb56037e6788d9880
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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