Ethyl 5-amino-1H-indole-2-carboxylate → HCID 59654757, compound

HRID 1444347Notes

Reaction equation

HRID 1444347 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[C:13]([C:15]([OH:17])=O)[CH:12]=[CH:11][CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:18]([O:20][C:21]([C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([NH2:32])=[CH:27][CH:26]=2)=[O:22])[CH3:19]>>[CH2:18]([O:20][C:21]([C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([NH:32][C:15]([C:13]1[CH:12]=[CH:11][CH:10]=[C:9]([C:4]3[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:14]=1)=[O:17])=[CH:27][CH:26]=2)=[O:22])[CH3:19]

Participants

3

Reactant 2

HCID 10726872Ethyl 5-amino-1H-indole-2-carboxylateHCID 24730153HCID 24730153, compound

Product 1

HCID 59654757HCID 59654757, compound

Procedure

Carboxylic acid (131) (50 mg, 0.19 mmol) was coupled to aniline (58) (42 mg, 0.21 mmol) using Method D to give the crude product.

Sources & evidence

ORD record
ord-87f3c63b887c4d21aae6c581bfc6a720
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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