6-Bromopyridine-2-carboxylic acid → 6-(3-Chlorophenyl)picolinic acid

HRID 1444348Notes

Reaction equation

HRID 1444348 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:13]=[C:14](B(O)O)[CH:15]=[CH:16][CH:17]=1>>[Cl:11][C:12]1[CH:17]=[C:16]([C:2]2[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=2)[CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 5939196-Bromopyridine-2-carboxylic acidHCID 2734323(3-Chlorophenyl)boronic acid

Product 1

HCID 247301356-(3-Chlorophenyl)picolinic acid

Procedure

6-Bromo-pyridine-2-carboxylic acid (200 mg, 0.99 mmol) was coupled to 3-chloro-phenylboronic acid (130 mg, 0.83 mmol) using Method F to give the title compound.

Sources & evidence

ORD record
ord-8a3cc2739e8249efb8c10b4baf43acb4
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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