HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminocinnamic acid ethyl ester → Ethyl 3-[3-[[[6-(3-chlorophenyl)-2-pyridinyl]carbonyl]amino]phenyl]-2-propenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| Reactant | 6-(3-Chlorophenyl)picolinic acid | HCID 24730135 | — |
| Product | Ethyl 3-[3-[[[6-(3-chlorophenyl)-2-pyridinyl]carbonyl]amino]phenyl]-2-propenoate | HCID 68497880 | — |
Reaction Steps
Carboxylic acid (136) (44 mg, 0.19 mmol) was coupled with aniline (60) (40 mg, 0.21 mmol) using Method D. The residue was purified by column chromatography eluting with a stepped gradient of 10-15% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662839B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-ebfe8ccc108743ae997506e032184736 |
| Source note | uspto-grants-2010_02 |