反应详情

The phenyl bromide (139) (50 mg, 0.13 mmol) was coupled to 3-chloro-phenylboronic acid (20 mg, 0.13 mmol) using Method E. During this reaction, hydrolysis occurred and the residue was extracted using Work-up E1. The crude product was then triturated with TBME (2 ml), DCM (2 ml), and recrystallised from a hot 10% EtOH in H2O mixture to give the title compound.

1. customDuring this reaction, hydrolysis
2. extractionthe residue was extracted
3. customThe crude product was then triturated with TBME (2 ml), DCM (2 ml)
4. customrecrystallised from a hot 10% EtOH in H2O mixture