5-Bromo-2-furanecarboxylic acid → 5-(4-Chlorophenyl)-2-furoic acid

HRID 1444356Notes

Reaction equation

HRID 1444356 reaction equation
Br[C:2]1[O:6][C:5]([C:7]([OH:9])=[O:8])=[CH:4][CH:3]=1.[Cl:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([C:2]2[O:6][C:5]([C:7]([OH:9])=[O:8])=[CH:4][CH:3]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 685115-Bromo-2-furanecarboxylic acidHCID 742994-Chlorophenylboronic acid

Product 1

HCID 7266935-(4-Chlorophenyl)-2-furoic acid

Procedure

5-Bromo-2-furoic acid (1 g, 5.25 mmol) was coupled to 4-chloro-phenylboronic acid (819 mg, 5.23 mmol) acid using Method F to give the title compound.

Sources & evidence

ORD record
ord-f8106d374ff5486bbd2cd0bd28485ae7
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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