4-Fluorophenylboronic acid → 6-(4-Fluorophenyl)picolinic acid

HRID 1444362Notes

Reaction equation

HRID 1444362 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 5939196-Bromopyridine-2-carboxylic acid

Product 1

HCID 210817086-(4-Fluorophenyl)picolinic acid

Procedure

6-Bromo-pyridine-2-carboxylic acid (1 g, 4.95 mmol) was coupled 4-fluoro-phenylboronic acid (693 mg, 4.95 mmol) acid using Method F to give the title compound.

Sources & evidence

ORD record
ord-da28926dc344423583ecf8f4e8699da5
Source dataset
uspto-grants-2010_02
Patent number
US07662839B2

Reaction notes

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