HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminocinnamic acid ethyl ester → 3-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| Reactant | 6-(4-Fluorophenyl)picolinic acid | HCID 21081708 | — |
| Product | 3-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester | HCID 68496911 | — |
Reaction Steps
Carboxylic acid (152) (50 mg, 0.23 mmol) was coupled to aniline (60) (44 mg, 0.23 mmol) using Method C. The crude residue was purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662839B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-d5283ba721b34739a930503b4ce80fc2 |
| Source note | uspto-grants-2010_02 |