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Ethyl 3-(3-Aminophenyl)propionate → 3-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]amino}-phenyl)-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(3-Aminophenyl)propionate | HCID 82314 | — |
| 反応物 | 6-(4-Fluorophenyl)picolinic acid | HCID 21081708 | — |
| 生成物 | 3-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]amino}-phenyl)-propionic acid ethyl ester | HCID 59654758 | — |
反応手順
Carboxylic acid (152) (50 mg, 0.23 mmol) was coupled to aniline (124) (45 mg, 0.23 mmol) using Method C. The residue was purified by column chromatography eluting with 30% EtOAc in heptane to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07662839B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-d2389b0fc4b04fe9949d6f0c27b80c19 |
| 出典メモ | uspto-grants-2010_02 |