(6-Methoxy-3,4-dihydronaphthalen-2-yl)trimethyltin → [3-Fluoro-4-(2-piperidin-1-ylethoxy)phenyl][4-methoxy-2-(6-methoxy-3,4-dihydro-naphthalen-2-yl)phenyl]methanone

HRID 144441Notes

Reaction equation

HRID 144441 reaction equation
[Br:1][c:2]1[c:3]([C:10](=[O:11])[c:12]2[cH:13][c:14]([F:27])[c:15]([O:18][CH2:19][CH2:20][N:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[cH:16][cH:17]2)[cH:4][cH:5][c:6]([O:8][CH3:9])[cH:7]1.[CH3:28][O:29][c:30]1[cH:31][c:32]2[c:37]([cH:38][cH:39]1)[CH:36]=[C:35]([Sn:40]([CH3:41])([CH3:42])[CH3:43])[CH2:34][CH2:33]2>>[c:2]1([C:35]2=[CH:36][c:37]3[c:32]([cH:31][c:30]([O:29][CH3:28])[cH:39][cH:38]3)[CH2:33][CH2:34]2)[c:3]([C:10](=[O:11])[c:12]2[cH:13][c:14]([F:27])[c:15]([O:18][CH2:19][CH2:20][N:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[cH:16][cH:17]2)[cH:4][cH:5][c:6]([O:8][CH3:9])[cH:7]1

Participants

3

Reactant 2

HCID 23087176(6-Methoxy-3,4-dihydronaphthalen-2-yl)trimethyltinHCID 57934302(2-Bromo-4-methoxyphenyl)[3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]methanone

Product 1

HCID 57934461[3-Fluoro-4-(2-piperidin-1-ylethoxy)phenyl][4-methoxy-2-(6-methoxy-3,4-dihydro-naphthalen-2-yl)phenyl]methanone

Sources & evidence

ORD record
ord-874222ffeacf44adab0c0dca61adaf68
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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