Aniline → 1,1,1-Trifluoro-4-phenyl-2-[(phenyl)iminomethyl]-4-methylpentan-2-ol

HRID 1444444Notes

Reaction equation

HRID 1444444 reaction equation
[OH:1][C:2]([C:15]([F:18])([F:17])[F:16])([CH2:5][C:6]([CH3:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[CH:3]=O.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[F:16][C:15]([F:18])([F:17])[C:2]([CH:3]=[N:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([OH:1])[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:14])[CH3:7]

Participants

3

Reactant 2

HCID 6115AnilineHCID 179890922-Hydroxy-4-methyl-4-phenyl-2-trifluoromethylpentanal

Product 1

HCID 179891091,1,1-Trifluoro-4-phenyl-2-[(phenyl)iminomethyl]-4-methylpentan-2-ol

Procedure

Analogously to Example 1, 200 mg of 2-hydroxy-4-methyl-4-phenyl-2-(trifluoromethyl)pentanal and 64 μl of aniline are converted into 180 mg of product.

Sources & evidence

ORD record
ord-2ec1f25001864eb1bf34e4f7894976b7
Source dataset
uspto-grants-2010_02
Patent number
US07662821B2

Reaction notes

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