HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthylamine → HCID 68681106, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthylamine | HCID 7057 | — |
| Reactant | 4-(2-Methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal | HCID 17989098 | — |
| Catalyst | Titanium isopropoxide | HCID 11026 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68681106 | HCID 68681106 | 89.8% |
Reaction Steps
150 mg (0.517 mmol) of 2-hydroxy-4-(2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-pentanal is converted into imine with 74 mg (0.517 mmol) of 2-naphthylamine in toluene with the aid of titanium tetraisopropylate. After working-up and chromatography, 192.8 mg (89.8%) of the desired imine is isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662821B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-734750eb979e40a28d0f15b5437352d3 |
| Source note | uspto-grants-2010_02 |