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HRID1444518

反应详情

EQUATION

反应方程式

HRID 1444518 的结构方程式

REACTANTS

反应物

3
结构：ClCCl
HCID6344

Dichloromethane

CH2Cl2

结构：Nc1cccc2[nH]c(=O)ccc12
HCID15719078

5-Aminoquinolin-2(1H)-one

C9H8N2O

结构：COc1cc(C)ccc1C(C)(C)CC(O)(C=O)C(F)(F)F
HCID17989127

未命名化合物

PRODUCTS

生成物

1
结构：COc1c(C)ccc2c1C(C)(C)CC(O)(C(F)(F)F)C2Nc1cccc2[nH]c(=O)ccc12
HCID68682487

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Cl][Ti]([Cl])([Cl])[Cl]
催化剂HCID24193

Titanium tetrachloride

Cl4Ti

PROCEDURE

实验过程

Analogously to Example 10, the corresponding imine is produced starting from 600 mg of 4-(2-methoxy-4-methylphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal and 315 mg of 5-aminoquinolin-2(1H)-one. 12 mg of the title compound is obtained by reaction of 370 mg of the imine with 8.3 ml of titanium tetrachloride (1 M in dichloromethane) in 20 ml of dichloromethane.