HCID 17989133, compound → HCID 17989219, compound

HRID 1444541Notes

Reaction equation

HRID 1444541 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([OH:19])[CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]([O:17][CH3:18])[CH:11]=1)([CH3:9])[CH3:8])[CH3:2]>ClCCl>[CH2:1]([O:3][C:4](=[O:20])[C:5](=[O:19])[CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]([O:17][CH3:18])[CH:11]=1)([CH3:9])[CH3:8])[CH3:2]

Participants

3

Reactant 1

HCID 17989133HCID 17989133, compound

Product 1

HCID 17989219HCID 17989219, compoundYield 89.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.78 g (9.78 mmol) of ethyl-4-(4-fluoro-3-methoxyphenyl)-2-hydroxy-4-methylpentanoate is oxidized as in Example 273 with SO3/Py in dichloromethane to the corresponding α ketoester. After chromatography on a Flashmaster, 2.48 g (89.9%) of the desired compound is obtained.

Sources & evidence

ORD record
ord-72a1d6244f7e429d8bcdcfaa3eaa2cd1
Source dataset
uspto-grants-2010_02
Patent number
US07662821B2

Reaction notes

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