Sodium Hydroxide → HCID 21962672, compound

HRID 1444564Notes

Reaction equation

HRID 1444564 reaction equation
C([O:3][C:4](=[O:26])[C:5]([NH:15][C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])([CH2:9][CH:10]([CH2:13][CH3:14])[CH2:11][CH3:12])[C:6]([OH:8])=[O:7])C.[OH-].[Na+]>C(O)C>[CH2:19]([O:18][C:16]([NH:15][C:5]([CH2:9][CH:10]([CH2:13][CH3:14])[CH2:11][CH3:12])([C:6]([OH:8])=[O:7])[C:4]([OH:26])=[O:3])=[O:17])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68716464HCID 68716464, compound

Product 1

HCID 21962672HCID 21962672, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Benzyloxycarbonylamino-2-(2-ethylbutyl)malonic acid monoethyl ester was heated at 75° C. in ethanol (5 mL) with sodium hydroxide (5 mL, 1 N) for 3 h and 2-benzyloxycarbonylamino-2-(2-ethylbutyl)malonic acid was isolated by extraction of the acidified reaction mixture. 2-Benzyloxycarbonylamino-2-(2-ethylbutyl)malonic acid was heated at 103° C. for 1 h and the resulting residue was purified by column chromatography on silica gel to give 2(RS)-benzyloxycarbonylamino-4-ethylhexanoic acid (0.220 g).

Sources & evidence

ORD record
ord-ad9ab6792d03483db0f076553fa776db
Source dataset
uspto-grants-2010_02
Patent number
US07662849B2

Reaction notes

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