Hydrochloric Acid → 2(S)-amino-1-(2-phenyl-[1,3]dithian-2-yl)-hexan-1-ol

Participants

Reaction Conditions

Reaction Steps

To {1-[hydroxy-(2-phenyl-[1,3]dithian-2-yl)methyl]pentyl}carbamic acid tert-butyl ester (608 mg, 1.47 mmol) in dioxane (2.7 mL) at 10° C. was added hydrochloric acid (2.7 mL, 4 M in dioxane). The solution was warmed to 23° C. After 3 h, the solution was diluted with toluene (5 ml) and concentrated under reduced pressure. The gummy solid was washed with diethyl ether resulting in the hydrochloride salt of 2(8)-amino-1-(2-phenyl-[1,3]dithian-2-yl)hexan-1-ol, (414 mg, 82%) as a free flowing solid after removal of excess ether under reduced pressure.

Provenance & Evidence