HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1444580Generated: October 27, 2026
p-Toluenesulfonic acid → Oxazolo(4,5-b)pyridine
https://huagongshe.com/reaction/1444580
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 2-Amino-3-Hydroxypyridine | HCID 28114 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Product | Oxazolo(4,5-b)pyridine | HCID 10103159 | — |
Reaction Steps
A mixture of 2-amino-3-hydroxypyridine (25 g, 227 mmol), triethylorthoformate (75 mL) and p-toluenesulfonic acid (61 mg) was heated at 140° C. for 8 h. Excess triethylorthoformate was removed under vacuum. The product was crystallized from ethyl acetate to yield 22.5 g of oxazolo[4,5-b]pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07662849B2 |
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| Source dataset | uspto-grants-2010_02 |
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| ORD ID | ord-87d1074a14bd4b028205d5bf7d16b128 |
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| Source note | uspto-grants-2010_02 |
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