Chlorotrimethylsilane → HCID 57462746, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2(S)-(tert-butoxycarbonyl)amino-1-benzoxazol-2-ylpropan-1-ol (26.3 g, 86 mmol) in isopropanol (118 mL) at 20-25° C. was added trimethylchlorosilane (1.4 eq). The solution was stirred for 5 h at 50° C. Concentration of the reaction mixture to 52 mL followed by addition of isopropyl ether (210 mL), filtration and drying under vacuum afforded 2(S)-amino-1-benzoxazol-2-yl-butan-1-ol hydrochloride salt as a grey solid (16.4 g; yield=79%; mixture of diastereomers.

Provenance & Evidence