N-Benzyl-1,4-dioxaspiro[4.5]decan-8-amine → 1,4-Dioxaspiro[4.5]decan-8-amine

Participants

Reaction Steps

Benzyl-(1,4-dioxa-spiro[4.5]dec-8-yl)-amine (6.4 mmol) was dissolved in EtOH (10 ml) and hydrogenated under nitrogen with Pd(C) 340 mg (0.32 mmol) with stirring overnight at RT. The reaction mixture was filtered out over Celite and washed with CH2Cl2. After removal of the solvent, the product 1,4-dioxa-spiro[4.5]dec-8-ylamine 824 mg (82% of theoretical) was obtained.

Provenance & Evidence