HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-[2-(2-aminophenyl)-3-cyclohexyl-6-(methoxycarbonyl)-1H-indol-1-yl]propanoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3-[2-{2-[(tert-butoxycarbonyl)amino]phenyl}-3-cyclohexyl-6-(methoxycarbonyl)-1H-indol-1-yl]propanoic acid | HCID 68693221 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[2-(2-aminophenyl)-3-cyclohexyl-6-(methoxycarbonyl)-1H-indol-1-yl]propanoic Acid | HCID 68696812 | — |
Reaction Steps
To a solution of 3-[2-{2-[(tert-butoxycarbonyl)amino]phenyl}-3-cyclohexyl-6-(methoxycarbonyl)-1H-indol-1-yl]propanoic acid in DCM (0.05 M) a large excess (>100 eq) of TFA was added and the solution was stirred at RT for 1 h. The volatiles were removed in vacuo to afford the title compound (quant); MS (ES+) m/z 421 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662809B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-306340aa76754280b54aa6716ef62f50 |
| Source note | uspto-grants-2010_02 |