Chloranil → beta-Alanine Benzyl Amine Urea

Participants

Reaction Steps

To a solution of β-alanine benzyl amide HCl (80 mg, 0.36 mmol) in N-methyl morpholine (120 μi) and MC (2 mL), triphosgene (0.72 mmol) was added at room temperature. After 10 minutes, the resulted isocyanate solution was added to a suspension of the secondary amine resin obtained in above step (2) (100 mg, 0.048 mmol) and kept shaking for 3 hrs at room temperature. The resin was washed with DMF, MeOH and MC, and the completion of reaction was checked with chloranil test.

Provenance & Evidence