beta-Alanine Benzyl Amine Urea → 1,7-Dibenzyl-6-oxo-octahydro-pyrimido[1,6-a]pyrimidin-2-one

HRID 1444680Notes

Reaction equation

HRID 1444680 reaction equation
[NH2:1][C:2]([NH2:4])=[O:3].[CH2:5]([NH2:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.N[CH2:14][CH2:15][C:16]([OH:18])=O>C(O)=O>[CH2:5]([N:12]1[C:16](=[O:18])[CH2:15][CH2:14][N:1]2[C:2](=[O:3])[N:4]([CH2:5][C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:16][CH2:15][CH:14]12)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 1

HCID 86761057beta-Alanine Benzyl Amine Urea

Product 1

HCID 469359991,7-Dibenzyl-6-oxo-octahydro-pyrimido[1,6-a]pyrimidin-2-one

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The thiourea group-containing resin of step (C) was treated with formic acid and kept shaking for 15 hrs. The resin was filtered off and the filtrate was concentrated and purified by chromatography (silica gel) to obtain the title compound.

Workup

  1. filtrationThe resin was filtered off
  2. concentrationthe filtrate was concentrated
  3. custompurified by chromatography (silica gel)

Sources & evidence

ORD record
ord-07300fed15094213a092c56fdc88f492
Source dataset
uspto-grants-2010_02
Patent number
US07662960B2

Reaction notes

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